Effect of felodipine combined with irbesartan on blood pressure control and carotid artery intima-media thickness in hypertensive patients / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of felodipine combined with irbesartan in the treat-ment of hypertension and its effect on atherosclerosis in remission .Methods 100 patients with hypertension were divided into the observation group and the control group .The control group was given the felodipine treatment ,the obser vation group was given felodipine treatment based on the control group .The treatment effect ,changes of blood control and carotid artery intima-media thickness were compared between the two groups .Results The total effective rate of the observation group was 90.0%,which was significantly higher than 72% of the control group (χ2 =3.85,P<0.05).After treatment,the systolic pressure,diastolic pressure of the observation group were significantly lower than those in the control group(t=4.21,5.05,all P<0.05).After treatment,the size,thickness of carotid artery plaque of the observation group were significantly lower than those of the control group (t =1.98,5.05,all P <0.05). Conclusion Felodipine combined with irbesartan can significantly improve the therapeutic effect of hypertensive patients,and can improve the control of blood pressure ,slow the progression of atherosclerosis .