Potassium antagonizes damage of coronary artery induced by high salt in-take / 中国病理生理杂志

ABSTRACT

AIM:To investigate the effect of potassium treatment on coronary arterial impairment induced by high salt intake.METHODS:Sprague-Dawley rats (4-week-old, n=10 in each group) received distilled water (NS), water containing 1.5%NaCl (HS), or 1.5% NaCl and 0.5% KCl (HS+HP) for 16 weeks.Systolic blood pressure (SBP) was determined by tail plethysmography every 2 weeks.After 16 weeks of treatment, vascular remodeling, superox-ide production, malondialdehyde (MDA) content, and endothelial nitric oxide synthase (eNOS) and gp91 expression in the coronary arteries were detected .RESULTS:After 16 weeks of salt loading , the rats in HS group was divided into salt sensitive subgroup and salt resistance subgroup according to the tail-cuff blood pressure .In this experiment , the salt-sensi-tive rats were selected as HS group .In HS group, salt loading significantly increased SBP , serum MDA and gp91 expres-sion, decreased serum NO and eNOS expression in the coronary arteries , and induced the coronary artery remodeling com-pared with NS group .In salt-loaded SD rats , 16-week potassium treatment abrogated the effects induced by salt loading . CONCLUSION:High salt may affect structural and functional changes in coronary arteries by activating oxidative stress . Potassium treatment antagonizes the effect of high salt intake .