Correlation between autophagy and type 2 diabetes:research advances / 国际药学研究杂志

ABSTRACT

Autophagy is a cellular reaction to the changes of internal and external environmental pressure, and a degradation process of the material composition. Recent study has shown that autophagy is closely related to the quantity and insulin secretion of pan-creaticβcell. As a self-protection mechanism, the activation and regulation of autophagy are essential for maintaining the structure and function of pancreaticβcells in type 2 diabetes. Moreover, some drugs for type 2 diabetes were found to participate in the regulation of autophagy pathway in recent studies. Thus, in this review we summarize the importance of autophagy in protecting the structure and func-tion of pancreaticβcell, the regulation of autophagy pathway and the correlation between autophagy and drugs for type 2 diabetes.