Diagnosis of one case with 7p15.3p22.1 microdeletion by applying array-based comparative genomic hybridization / 临床儿科杂志
Journal of Clinical Pediatrics
;
(12): 757-759, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-454105
ABSTRACT
Objective To investigate the diagnosis of a case with 7p15.3p22.1 microdeletion by applying array-based comparative genomic hybridization (array-CGH) and to analyze the relationship between the clinical manifestations and 7p15.3p22.1 microdeletion. Method Array-CGH technique was used to detect genomic copy number variations (CNVs) in an infant with normal karyotype after conventional chromosomal karyotyping. Results Array-CGH detected 7p15.3p22.1 deletion (chr7 6777262-23981753), which was confirmed as pathogenic CNV after comparative analysis with database. Conclusion Array-CGH could serve as a useful complement for G-banding to be used in the clinical cytogenetic diagnosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude diagnostique
langue:
Chinois
Texte intégral:
Journal of Clinical Pediatrics
Année:
2014
Type:
Article
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