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Risk Factors for Aseptic Meningitis in Herpes Zoster Patients
Annals of Dermatology ; : 283-287, 2017.
Article Dans Anglais | WPRIM | ID: wpr-45442
ABSTRACT

BACKGROUND:

Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period.

OBJECTIVE:

A retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development.

METHODS:

We included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis.

RESULTS:

The demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (p=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, p=0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (p=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (p=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (p=0.006).

CONCLUSION:

In HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Patients en consultation externe / Modèles logistiques / Odds ratio / Démographie / Études rétrospectives / Facteurs de risque / Herpèsvirus humain de type 3 / Dermatologie / Exanthème / Zona Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains / Mâle langue: Anglais Texte intégral: Annals of Dermatology Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Patients en consultation externe / Modèles logistiques / Odds ratio / Démographie / Études rétrospectives / Facteurs de risque / Herpèsvirus humain de type 3 / Dermatologie / Exanthème / Zona Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains / Mâle langue: Anglais Texte intégral: Annals of Dermatology Année: 2017 Type: Article