Clinical application of microRNA in gastric cancer / 中华检验医学杂志

ABSTRACT

microRNAs ( miRNAs) are a class of endogenous noncoding small molecular RNAs , which regulate target gene expression at the post-transcriptional level and play vital roles in cell development , proliferation, differentiation, tumorigenesis and other biological behavior.Changes in miRNA expression profiles have been observed in gastric cancer in recent studies.Further studies demonstrated that miRNAs were closely related to the carcinogenesis , development and metastasis of gastric cancer , which suggested miRNAs have broad prospective application in diagnosis and therapy of gastric carcinoma as biomarkers and therapeutic targets.