Clinical significance of serum cystatin C combined with brain natriuretic peptide in early diagnosis of con-trast-induced nephropathy / 中国基层医药

ABSTRACT

Objective To explore the clinical significance of serum cystatin C (Cys C) combined with brain natriuretic peptide(BNP)in more earlier,more accurate diagnosis of contrast-induced nephropathy(CIN)after coro-nary angiography or percutaneous coronary intervention .Methods 358 patients undergone coronary angiography or percutaneous coronary intervention were enrolled in this study , and the data were collected .The serum creatinine (Scr),Cys C and BNP were tested before operation .The serum Cys C and BNP were tested 8h,16h,24h after opera-tion.The serum Scr was tested 24h,48h,72h after operation.All patients were diagnosed and grouped with CIN by ser-um Scr.The results were compared between the CIN group and control group ,diagnosis efficiency of Cys C ,BNP and combine with them was analyzed .Results CIN occurred in 16 cases of 358 enrolled patients , the incidence was 4.47%.The levels of Scr increased beyond 24h after operation in the CIN group .The levels of serum Cys C and BNP had no significant difference at 8h after operation compared to preoperation (P>0.05),and significantly rosed at 16h and 24h after operation(P0.05),and significantly rosed at 16h and 24h after operation in CIN( P<0.01)than the corresponding levels in the control group [16h Cys C(1.63 ±0.49)mg/L vs(0.93 ±0.38)mg/L,24h Cys C(3.45 ±0.83)mg/L vs(0.92 ±0.34)mg/L,16h BNP(215.96 ±55.72)ng/L vs(149.32 ±43.74)ng/L,24h BNP(352.41 ±61.08)ng/L vs(164.82 ±49.62)ng/L,all P<0.01].The diagno-sis efficiency of serum Cys C combined with BNP at 16h after operation had high degree of accuracy .Conclusion In this study,the serum Cys C and BNP are better biomarker for early diagnose of CIN ,witch can diagnose CIN earlier than Scr .Combine of the two biomarker can more earlier ,more accurate diagnose CIN .