Research progress of BARD1 in tumors / 肿瘤研究与临床

ABSTRACT

BRCA1-associated RING domain 1(BARD1) is composed with ring finger,ankyrin repeats and BRCT (BRCA1 C-terminus) domain.The special structure is involved in many essential biological processes such as DNA repair,cell survival and apoptosis,proteasome dependent protein degradation and so on.The abnormal expression of BARD1 is closely related with the occurrence and progression of carcinoma.Aberrant splice variants of BARD1 are very potential tumor markers for cancer diagnosis.