Meta analysis for the association between a genetic variant in gene Dicer and cancer susceptibility / 国际检验医学杂志
International Journal of Laboratory Medicine
; (12): 2872-2874, 2014.
Article
de Zh
| WPRIM
| ID: wpr-459227
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the association between a genetic variant in Dicer and cancer risk .Methods Both English and Chi-nese databases were carefully searched comprehensively .Based on the including and excluding criteria ,literatures that were eligible were carefully screened and data were retrieved .Meta analysis was performed by RevMan 5 .1 software .Pooled odds ratios(OR) and 95% confi-dential interval(CI)were used for analysis .Results Ten eligible literatures were included in the meta analysis .Meta analysis showed that the mutant allele C in 3′untranslated region polymorphism loci rs1057035 of Dicer gene might reduce the cancer risk(OR=0 .92 ,95% CI=0 .87-0 .97 ,P=0 .003) .Conclusion The variant rs1057035 T>C in Dicer gene could be related to cancer susceptibility .
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Systematic_reviews
langue:
Zh
Texte intégral:
International Journal of Laboratory Medicine
Année:
2014
Type:
Article