Research progress of Sox-2 signaling regulation pathway and its mechanism in tumor development / 医学研究生学报
Journal of Medical Postgraduates
; (12): 313-317, 2015.
Article
de Zh
| WPRIM
| ID: wpr-460601
Bibliothèque responsable:
WPRO
ABSTRACT
Sox-2(SRY related HMG box-2)is an essential embryonic stem cell gene and a necessary transcription factor for maintaining the proliferation and self-renewal capability of embryonic stem cell .Sox-2 is involved in complex cell signal transduction pathway network and adjusting biological behavior of cells .Expression of Sox-2 is adjusted by different factors in transduction , transla-tion and post-translation levels .In recent years , increasing evidences indicate Sox-2 has an important role in tumor development , growth, proliferation, and metastasis, which is involved in various biological behavior of tumor cells in many types of tumors .This pa-per reviews the role of Sox-2 in adjusting tissue and tumor development and complex cell signal transduction pathway network of Sox -2 and clinical values of Sox-2 in tumor diagnosis and treatment until now .
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Medical Postgraduates
Année:
2015
Type:
Article