Acellular matrix scaffold for tissue-engineered intervertebral disc which is closest to the normal three-dimensional structure of the nucleus pulposus / 中国组织工程研究

ABSTRACT

BACKGROUND:At present there is no specific therapy for the treatment of degenerateive disc diseases. The development of tissue engineering technology provides a new therapy idea for it. OBJECTIVE:To review the research progress of acelular matrix scaffold to construct tissue-engineered intervertebral disc. METHODS:A computer-based online search of PubMed, CNKI, Wanfang and Chinese Biomedical Database was performed for relevant articles published between 2005 to 2014 using the keywords of “intervertebral disc degeneration, extracelular matrix, tissue engineering, scaffold, nucleus pulposus, annulus fibrosus” in English and Chinese, respectively. RESULTS AND CONCLUSION:Construction of tissue-engineered intervertebral disc includes three essential elements: cel scaffolds, seed cels and cytokines. Scaffolds are the key. Acelular matrix scaffold is an important scaffold which has been a hot area of research in scaffolds for tissue-engineered intervertebral disc for several years, which can be divided into three types: acelular annulus fibrosus scaffold, acelular nucleus pulposus scaffold and integrated intervertebral disc scaffold. Different scaffolds have a variety of preparation methods. Acelular matrix scaffold has its own significant advantages, such as low antigenicity, good histocompatibility, and a most similarity with the three-dimensional structure of normal nucleus pulposus that can provide a proper microenvironment for cel growth. However, there are stil some disadvantages of acelular matrix scaffold in tissue-engineered intervertebral disc. So, it needs to be further improved.