Lactose intolerance in lactase - deficient subjects and patients with inflammatory bowel disease after drinking common doses of milk / 대한내과학회지
Korean Journal of Medicine
;
: 569-575, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-46091
ABSTRACT
OBJECTIVE:
To define whether lactase-deficient subjects are intolerable to even a pack of milk(200ml) and whether milk intolerance in the patients with IBD is only due to lactose malabsorption, we performed this study.METHODS:
We evaluated 32 healthy adults and 12 patients with active stage of inflammatory bowel disease(IBD) who had not received antibiotics therapy within the previous 3 weeks. Thirty-two healthy adults underwent H2-breath test with 200, 400, 600 and 800ml of milk at 1st, 2nd, 3rd and 4th day of study, respectively. We measured their end-expiratory hydrogen concentrations and asked them to record the gastrointestinal symptoms. Twelve patients with IBD were tested only with 200ml of milk. Lactose malabsorption was defined as the increase of 20ppm over basal H2 concentration and lactose intolerance as having two or more of the following symptoms; abdominal pain, diarrhea, borborygmus and flatus.RESULTS:
The prevalence of lactase deficiency was 72%(23 of 32 subjects) at 800ml of milk(lactose 40g). Among the lactase-deficient subjects, lactose intolerance at 200ml of milk(lactose 10g) was noticed only in 13%(3 of 23 subjects). In the patients with active stage of IBD, the frequency of milk intolerance at 200ml of milk was 50%(6 of 12 subjects), which was higher than in the healthy adults(9%). But the prevalence of lactose malabsorber in the patients with IBD at 200ml of milk(17%) was not higher than in the healthy adults(16%).CONCLUSION:
Most of lactase-deficient subjects(87%) can ingest one pack of milk without lactose intolerance. The increased prevalence of lactose intolerance in the patients with IBD at 200ml of milk is not originated from lactose malabsorption, but probably from incomplete colonic compensation salvage.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladies inflammatoires intestinales
/
Douleur abdominale
/
Prévalence
/
Côlon
/
Indemnités compensatoires
/
Lactase
/
Lait
/
Diarrhée
/
Consommation de boisson
/
Météorisme
Type d'étude:
Étude de prévalence
Limites du sujet:
Adulte
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
1999
Type:
Article
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