The clinical observation of the effects of maternal serum vitamin D levels on the developing nervous system in infants / 重庆医学

ABSTRACT

Objective To investigate the effect of maternal serum vitamin D (VD)levels on the developing nervous system in in-fants.Methods A total of 1 012 pregnant women's serum VD levels of early pregnancy were given the right amount of VD supple-mentation according to the results.They were divided into 3 groups (normal,deficiency and insufficiency group)according to the third trimester VD levels;and their infants 6-8 months were tested on the developmental quotient (DQ),mental index (MI)and other neurological development index by the Developmental Screening Test for child under six(DST).Results There were up to 94.17% of pregnant women in early pregnancy had severe VD deficiency,the average levels was (16.21 ± 7.54)ng/mL;Although VD levels was increased after supplements,there were 46.25% of pregnant women still deficient in VD.The average DQ score of 1 020 infants was 92.67±16.45 and M1 score was 97.53±17.04,which accorded with normal distribution.The rate of the infants born by mothers who had the normal VD levels were superior to those with VD deficiency and insufficiency on the quotients of out-standing and smart,and there was a significant difference between them(P 0.05).The level of VD was positively correlated with DQ and MI,and the correlation coefficients are 0.63 and 0.2(slightly correlated),respectively.Conclusion It should be pay more attention to monitoring the VD levels of the pregnant women during the pregnancy,and for lack should be promptly added.