Measuring Low Density Lipoprotein Cholesterol: Comparison of Direct Measurement by HiSens Reagents and Friedewald Estimation / 가정의학회지
Korean Journal of Family Medicine
; : 168-173, 2015.
Article
de En
| WPRIM
| ID: wpr-46109
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Directly measured low density lipoprotein cholesterol (DLDLC) has been reported to be more accurate than calculated low density lipoprotein cholesterol (CLDLC) using the Friedewald equation. However, some limitations of DLDLC have been reported. In this study, we evaluated differences between CLDLC and DLDLC measured using HiSens reagents. METHODS: Data were collected from 582 persons undergoing routine physical examinations at a general hospital. LDLC measurements were made directly or estimated using the Friedewald formula, and were classified according to the National Cholesterol Education Program's Adult Treatment Panel III guidelines. The relationship between these differences and other clinically relevant factors, such as triglyceride (TG) levels, were examined using multiple logistic regression analysis. RESULTS: The DLDLC and CLDLC were strongly correlated according to simple linear regression analysis (r=0.917, P0.5). CONCLUSION: Unlike other studies, DLDLC was significantly lower than CLDLC and the large differences in LDLC concentrations were not dependent on TG concentration. Our work suggests that verification of DLDLC accuracy is needed and differences in LDLC measurements should be accounted for in making clinical decisions.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Examen physique
/
Grèves
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Triglycéride
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Biais (épidémiologie)
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Modèles linéaires
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Modèles logistiques
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Cholestérol
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Éducation
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Hôpitaux généraux
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Indicateurs et réactifs
Type d'étude:
Guideline
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Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Humans
langue:
En
Texte intégral:
Korean Journal of Family Medicine
Année:
2015
Type:
Article