Clinical features of child mitochondrial encephalopathy with lactic acidosis and stroke with status epileptics / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 160-163, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-462022
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate the clinical features and treatment of a group of patients of mitochondrial encepha-lomyopathy with actic acidosis and stroke (MELAS) with onset of status epileptics. Methods Clinical features, EEGs, image ifndings, and therapeutic data of 4 cases with onset of status epileptics patients ifnally diagnosed as MELAS were retrospectively reviewed. Results Four Patients were onset with status epileptics. The levels of serum lactic acid, ammonia, myocardial enzymes were increased, and the serum sodium level was reduced, and accompanied with metabolic acidosis. EEG found corresponding paroxysmal and interictal activities. Brain images showed basal ganglia calciifcation, brain atrophy, and acute cortex edema. Genetic detection found mtDNA3243 mutation. Conclusions The status epilepticus was commonly present in MELAS. The treatment of epileptic attack in this disease was dififcult, which needs early diagnosis. Appropriate anti-leptic drugs and relevant treatment to symptoms are important to alleviate cerebral injury.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Screening_studies
langue:
Zh
Texte intégral:
Journal of Clinical Pediatrics
Année:
2015
Type:
Article