Influence of CYP3A and MDR1 genetic polymorphisms on the pharmacokinetics of ciclosporin A / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 148-151, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-464620
ABSTRACT
Ciclosporin A (CsA), an immunosuppressive macrolide antibiotics, is widely applied to prevent rejections after organ transplants. CsA is mainly transported by P-glycoprotein (P-gp) and metabolized by cytochrome P450 (CYP450) 3A.Genetic polymorphisms of CYP3A and MDR1 probably influence the expressions and bioactivity of CYP3A and P-gp,and may affect the pharmacokinetics of CsA.This issue summarizes the correlation between genetic polymorphisms of CYP3A and MDR1 and the pharmacokinetics of CsA to guide the rational and individualized medication.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of International Pharmaceutical Research
Année:
2015
Type:
Article
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