The analysis of laboratory indexes in type 2 diabetes mellitus patients with hypoglycemia / 国际检验医学杂志

ABSTRACT

Objective To analyze the laboratory indexes related to type 2 diabetes mellitus(T2DM ) and to explore whether hy‐poglycemia would aggravate the injury of body and development of complication .Methods 27 cases of patients with T2DM from Jan .to Jun .2014 were enrolled in hypoglycemia group ,and 80 patients of diabetes mellitus without hypoglycemia were enrolled in non‐hypoglycemia group .The laboratory indexes were compared between the two groups ,and the relationship between incidence rate of hypoglycemia and levels of glycosylated hemoglobin (HbAc1) were also analyzed ..Results The age ,course of the disease , levels of alanine aminotransferase (ALT ) and serum creatinine (SCr) and urinary protein excretion (Upro ) in the hypoglycemia group were higher than those in the non‐hypoglycemia group ,there were statistical significant differences (P0 .05) .The levels of creatine kinase(CK) ,high sensitivity C‐reactive protein(hs‐CRP) and fibrinogen(FIB) in pa‐tients with T2DM after developing hypoglycemia were higher than those in patients before developing hypoglycemia ,while superox‐ide dismutase(SOD) was lower ,there were statistical significant differences (P0 .05) ,at the same time the risk of hypoglycemia tended to be higher in patients with near‐normal level of HbA1c than patients with poor HbA1c control .Conclusion The older , long course of disease and near‐normal levels of HbA1c controled in patients with T2DM may be prone to develop hypoglycemia . Hypoglycemia could aggravate the body injury and speed up the development of complications of T 2DM .