Silicone materials for breast augmentation influence the state of human oral mucosa cells / 中国组织工程研究

ABSTRACT

BACKGROUND:Previous studies have shown that the survival state of oral mucosal cels directly is directly affected by the nutritional status of the body, therefore, it may be a good indicator of the surgical nutritional status. But whether this index also influences surgical trauma stimulus is stil unclear. OBJECTIVE: To observe the effect of breast augmentation with silicone implants on the survival status of oral mucosal cels. METHODS: Thirty-two female patients scheduled for breast augmentation with silicone implants, including 13 cases of reproductive history and 19 cases of non-reproductive history, aged 23-45 years old. Sub-G1 peak method and Ki-67 were used to detect the proliferation and apoptosis rates of oral mucosa cels before and after breast augmentation with silicone implants for statistical comparisons. RESULTS AND CONCLUSION:Al the 32 cases successfuly completed breast augmentation with silicone implants, and no serious adverse events occurred perioperatively. The oral mucosa cel apoptosis and proliferation rates were (27.3±6.2)% and (27.8±5.8)% before breast augmentation, and (27.8±5.8)% and (20.2±7.7)% after breast augmentation. There was no difference before and after breast augmentation (P > 0.05). These findings indicate that the proliferation and apoptosis of human oral mucosa cels cannot be significantly by breast augmentation-related trauma, and the survival state of oral mucosa cels has some value to assess the nutritional state of breast augmentation recipients.