Plasma myeloperoxidase, malondialdehyde, superoxide dismutase, and total anti-oxidant capability of Henoch-Sch?nlein purpura in children / 临床儿科杂志

ABSTRACT

ObjectiveTo investigate the changes in plasma myeloperoxidase (MPO), malondialdehyde (MDA), super-oxide dismutase (SOD) and total anti-oxidant capability (T-AOC) of Henoch-Sch?nlein purpura in children.MethodsA total of 80 HSP children hospitalized from November 2013 to April 2014 were selected including 40 cases of arthritis type, 20 cases of abdominal type and 20 cases of nephritis type (HSPN). Meanwhile, 16 healthy check-up children were selected as controls. Plas-ma MPO, T-AOC levels were detected by chemical colorimetry and MDA levels were detected by thiobarbituric acid colorime-try. Plasma SOD levels were measured by hydroxylamine method. Furthermore, 24-hour urine protein and other hematological indices were routinely tested.ResultsThe plasma levels of MPO, MDA, SOD and T-AOC were signiifcantly different among control group, arthritis type group, abdominal type group and HSPN group (F=24.22-126.99, allP=0.000). In comparison to oth-er three groups, the levels of MPO and MDA were signiifcantly increased and the levels of SOD and T-AOC were signiifcantly decreased in HSPN group (P<0.05). Compared with control group, the levels of MPO and MDA were signiifcantly higher and the levels of SOD and T-AOC were signiifcantly lower in arthritis and abdominal type groups (P<0.05). The levels of MPO and MDA in HSPN group were signiifcantly positively correlated with 24-hour urine protein (r=0.695, 0.559; bothP<0.01).Conclu-sionsThe imbalance between oxidation and antioxidant system exists in children with Henoch-Sch?nlein purpura.