Research on Correlation between rs13266634 C/T SNP of SLC30A8 Gene and Susceptibility to Type 2 Diabetes Mellitus / 中国医科大学学报

ABSTRACT

Objective To investigate the correlation between the rs13266634 C/T SNP of SLC30A8 and T2DM in Jinzhou. Methods Based on case?control study,PCR?HRM was used to identify the genotypes of rs13266634 of SLC30A8 gene in 136 cases of T2DM patients and 145 cases of healthy control in Jinzhou. Results The CC genotypic frequency and C allele frequency in T2DM(38.23%and 61.76%)were higher than those of healthy control(22.07%and 51.03%). Furthermore,there was significant difference in case?control study from the population in Jinzhou(P<0.05). The odds ratio of allele C for T2DM was 1.550(95%CI1.108?2.169,P<0.05). Conclusion The single nucleotide polymorphism of the rs13266634 locus in SLC30A8gene was correlated with T2DM susceptibility in Jinzhou,and the allele C was a risk allele.