Analysis of insulin resistance and islet beta cell function under different glucose metabolic state in the elderly / 中华老年医学杂志

ABSTRACT

Objective To detect and analyze the insulin resistance and islet beta cell function under different glucose metabolic state in the elderly.Methods 30 cases with impaired fasting glucose (IFG),impaired glucose tolerance (IGT),IFG plus IGT,diabetes mellitus (DM) and normal glucose tolerance (NGT) respectively were selected.The HOMA model was adopted for assessing insulin resistance and islet beta cell function.Results Insulin resistance index (HOMA-IR) was higher in IFG group (1.16±0.03) than in NGT group (0.87±0.03) (P＜0.05).The HOMA-IR was higher in IFG and IGF groups than in NGT group (both P＜0.05).The insulin secretion index (HOMA-IS) was lower in DM (3.95±0.06) than in NGT (5.15±0.05),IGT (5.13±0.03) and IFG (4.56 ± 0.07) groups (all P＜0.05).There was no significant difference in the HOMA-IS between IGT and NGT groups.Conclusions The IFG patients mainly present the defect in insulin secretion,and the IGT patients mainly present insulin resistance.With the deterioration of glucose metabolism,insulin resistance increases and islet beta cell function decays gradually.