Research progress of application of immunotherapy by chimeric antigen receptor-engineered T cells / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 139-141, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-470883
ABSTRACT
The technique of chimeric antigen receptor-engineered T cells (CAR-T) is combined single chain antibody and T-cell activation modification and has specific and durable killing effect on tumors.It had achieved stunning results on clinical trials of B lymphocytic leukemias,B lymphomas and solid tumors.Meanwhile it also had potential risk on the off target effects,cytokine release syndrome,graft versus host disease and so on.This paper briefly reviews the principal of CAR-T cellular mechanism,advantages and clinical applications.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Cancer Research and Clinic
Année:
2015
Type:
Article
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