6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 109-113, 2012.
Article
Dans Coréen
| WPRIM
| ID: wpr-47107
ABSTRACT
Hepatic sinusoidal obstruction syndrome (hSOS) can be developed as a common complication after hematopoietic stem cell transplantation (HSCT), and rarely after 6-thioguanine-based chemotherapy without HSCT. A four-year-old boy with heterozygotic polymorphism for thiopurine methyltransferase (TPMT) developed hSOS after he received chemotherapy with cytarabine, cyclophosphamide, intrathecal methotrexate and 6-thioguanine (6-TG) as reconsolidation chemotherapy of acute lymphoblastic leukemia (ALL). He was treated with defibrotide, N-acetylcysteine, urusodeoxycholic acid, glutathione, and supportive care. He recovered completely in nine days without long-term complication, and completed chemotherapy with 6-mercaptopurine without severe complication. We report a case of hSOS developed in an ALL patient with TPMT heterozygote after 6-TG based reconsolidation chemotherapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polydésoxyribonucléotides
/
Acétylcystéine
/
Tioguanine
/
Maladie veno-occlusive hépatique
/
Méthotrexate
/
Transplantation de cellules souches hématopoïétiques
/
Cyclophosphamide
/
Cytarabine
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Glutathion
Limites du sujet:
Enfant
/
Humains
langue:
Coréen
Texte intégral:
Clinical Pediatric Hematology-Oncology
Année:
2012
Type:
Article
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