Efficacy of thalidomide plus MP regimen for treatment of the patients with multiple myeloma / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 82-85, 2011.
Article
de Zh
| WPRIM
| ID: wpr-471246
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To compare the efficacy and toxicity of melphalan + prednisone + thalidomide regimen (MPT) and melphalan + prednisone regimen (MP) in the treatment of multiple myeloma (MM).was given 100-200 mg/d everyday. 21 cases in MP group, the dose of melphalan and prednisone were the same as that in MPT group. The efficacy was evaluated after 6 cycles of treatment. Results The overall response rate (ORR) of MPT group and MP group were 65.4 % and 42.9 %, respectively (P>O.05). The median response time in MPT group versus MP group was 2 months versus 3 months. Compared with the MP group. the increase of hemoglobin and albumin concentration in the MPT group is significantly higher (P< 0.05).The incidence of adverse effects of MPT group was higher than that of MP group (P <0.05), but the percentage of grade 3 and grade 4 toxicity was no different. The median PFS in MPT group was 11 months, 2-year PFS was 66.18 %. Conclusion Compared with MP, MPT could achieve higher response rate, improve the life quality and prolong the survival time of MM patients with better tolerance.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Leukemia & Lymphoma
Année:
2011
Type:
Article