Clinical study on modified GMALL protocol for adult acute lymphoblastic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 168-171, 2011.
Article
de Zh
| WPRIM
| ID: wpr-471339
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To analyze the treatment efficacy and safety of a modified GMALL protocol for adult acute lymphoblastic leukemia (ALL). Methods Data of 37 patients with newly diagnosed adult ALL treated with a modified GMALL protocol from January 2005 to December 2009 were retrospectively analyzed,and compared with that of 44 patients treated with an in-house conventional protocol at the same period.Results The complete remission (CR) rate was 89.2 %(33/37) treated with modified GMALL protocol. The cumulative overall survival (OS) rates at 1 year, 2 years, 3 years and 4 years were 77.5 %, 48.0 %, 40.0 %and 40.0 %, respectively. The main adverse events were grade 3 or grade 4 hematological toxicities and infections which were easily managed, and the treatment-related mortality rate was low. The OS of modified GMALL protocol was superior to that of the conventional protocol. Conclusion The modified GMALL protocol has a satisfying effect and the adverse events can be tolerated for adult ALL, so its clinical application can be encouraged.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Guideline
langue:
Zh
Texte intégral:
Journal of Leukemia & Lymphoma
Année:
2011
Type:
Article