Clinical effect of omeprazole combined with antibiotics in the treatment of peptic ulcer / 中国基层医药

ABSTRACT

Objective To explore the efficacy and adverse reaction of combined application of omeprazole and antibiotics in treatment of peptic ulcer.Methods 92 peptic ulcer patients in our hospital from 2013 March to 2014 March were selected.According to treatment methods,they were divided into the observation group and control group,46 cases in each group.The control group was given cimetidine,amoxicillin metronidazole treatment;the observation group was given omeprazole,amoxicillin and metronidazole treatment.The clinical efficacy and adverse reactions of the two groups were analyzed.Results The clinical efficacy of the observation group after treatment was 93.48 ％,which was significantly higher than 78.26％ of the control group (x2 =8.930,P ＜ 0.05).The abdominal distention,stomach burning sensation grades of the observation group were significantly better than the control group (t =7.42,8.03,P ＜ 0.05).Conclusion The combined application of omeprazole and antibiotics has obvious effect in treatment of ulcer disease,and it is safe and reliable,which is worthy of clinical application.