Research progress of mammalian target of rapamycin and hypoxia-inducible factor-1 in malignant tumors / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 429-432, 2015.
Article
de Zh
| WPRIM
| ID: wpr-475677
Bibliothèque responsable:
WPRO
ABSTRACT
Malignant tumor is an individual disease that caused by gene mutation and disorder of protein expression.The abnormity of mammalian target of rapamycin (mTOR) signaling pathways is closely related to the tumors,and its main biological function is the regulation of protein synthesis and vascular endothelial cell proliferation.However,the activation of mTOR can increase the expression of hypoxia-inducible factor-1 (HIF-1),maintain the acid microenvironment of tumor,promote tumor cell invasion and metastasis,and affect prognosis of tumor.At present,targeted therapy with mTOR and HIF-1 for new targets and gene therapy have become hot points.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Cancer Research and Clinic
Année:
2015
Type:
Article