Progress in biomarkers of cyclosporine A associated nephrotoxicity / 国际儿科学杂志

ABSTRACT

Cyclosporine A (CsA)has been widely used in steroid-dependent and steroid-resistant nephrotic syndrome as a common drug.However,renal toxicity can often occur at the same time which limited the use of CsA.CsA can lead to acute and chronic renal damage,ischemic renal tissue inflammation,and fibrosis.Currently in clinical practice,urine micro proteins and serum creatinine have been used to monitor CsA associated nephrotoxicity.However,this method cannot detect CsA associated renal damage in early stage.At present,a hot topic about CsA focuses on looking for a better non-invasive and sensitive way to monitoring CsA associated nephrotoxicity.This article reviews the current progress of known acute kidney injury biomarkers in momtoring CsA associated nephrotoxicity.