Analysis of autoantibody screening results of different gestational thyroid / 中国医师进修杂志

ABSTRACT

Objective To discuss the effect of autoantibodies positive on maternal and infant combined with literature by investigating the positive rate of different gestational thyroid autoantibodies,so as to improve the diagnosis and treatment of diseases.Methods A total of 549 cases of pregnant women were divided into early pregnancy group (178 cases),middle pregnancy group(192 cases),late pregnancy group (179 cases).The level of thyroid peroxidase antibody (TPOAb),thyroglobuhn antibody (TGAb),thyroid stimulating hormone receptor antibody (TRAb),thyroid stimulating hormone (TSH) were determined by electrochemiluminescence.And compared with 200 healthy people (control group).Results The positive rate of TPOAb was 18.54％ (33/178),the positive rate of TGAb was 19.66％ (35/178),the positive rate of TRAb was 0.56％ (1/178) in early pregnancy group.The positive rate of TPOAb was 15.62％ (30/192),the positive rate of TGAb was 16.15％ (31/192),the positive rate of TRAb was 0.52％ (1/192) in middle pregnancy group.The positive rate of TPOAb was 16.20％ (29/179),the positive rate of TGAb was 16.76％ (30/179),the positive rate of TRAb was 0.56％ (1/179) in late pregnancy group.The median TPOAb TGAb and the positive rate in early pregnancy group was higher than that in middle pregnancy group,late pregnancy group and control group,the difference was statistically significant (P ＜ 0.01).The median TPOAb,TGAb and the positive rate in middle pregnancy group was higher than that in late pregnancy group and control group,the difference was statistically significant (P ＜ 0.01).Conclusion More attention should be paid to gestational thyroid autoantibodies incidence,take the necessary intervention should be of high risk pregnant women.