Analysis of Characteristics of Serum Protein Electrophoresis in Chronic Heart Failure Patients and its Correlation with Prognosis / 现代检验医学杂志

ABSTRACT

Objectives To analyze the characteristics of serum protein electrophoresis(SPE)in chronic heart failure(CHF) patients,evaluate prognostic value and explore the reason of it preliminarily.Methods Retrospective exploration of 6 1 8 chronic heart failure patients in study cohort (CHF cohort)and 70 patients with normal cardiac function in control cohort was made to comp are the difference of serum protein electrophoresis.Then,CHF Patients were tracked down by phone to discuss the correlation between adverse event rate (re-hospitalization rate or mortality rate)and their SPE.Last,the multiple linear regression analysis of SPE and biochemical indicators was made to explore the reason of the abnormality.Results Pa-tients of CHF cohort appeared to have significantly rising beta 1-gobulin(6.01±1.06)%,compared with control cohort(t=3.417,P<0.001).Post-discharge adverse event rate displayed by the curve demonstrated that patients with beta 1-gobulin higher than or equal to 6% had much more adverse event rate than those with beta 1-gobulin less than 6%,in 7 to 24 months after discharged from the hospital,which had been proved by the Chi-square test of 0.031(P<0.05).Multiple linear regres-sion analysis showed that beta 1-globulin and serum creatinine,uric acid,and sodium were significantly correlated.Conclusion CHF patients had higher beta 1-gobulin of SPE probably because of immunoactivation,which may increase their re-hospi-talization rate ormortality rate after hospital discharge.Meanwhile,growing beta 1-gobulin is closely correlated with blood creatinine,uric acid and blood natrium and becomesa risk of kidney dysfunction due to hypoperfusion and accumulation of se-rum immunoglobulin.