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Preliminary study on prevalence and transmission route of Klebsiella pneumoniae carbapenemases-producing Klebsiella pneumoniae / 中华临床感染病杂志
Article de Zh | WPRIM | ID: wpr-476441
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the prevalence and transmission route of Klebsiella pneumoniae carbapenemases ( KPC)-producing Klebsiella pneumoniae in Xinhua Hospital Affiliated to Shanghaijiao Tong University School of Medicine .Methods Carbapenem-resistant Klebsiella pneumoniae isolates from clinical samples were collected from Xinhua Hospital during January 2010 and December 2013.Vitek 2 Compact and disc diffusion method ( Kirby-Bauer method ) were used for identification of the strains and antibiotic susceptibility test . Modified Hodge test was performed for drug-resistant phenotype screening . Carbapenemase gene blaKPC was amplified by PCR, and the positive products were sequenced and analyzed . Enterobacterial repetitive intergenic consensus ( ERIC )-PCR was used to analyze molecular epidemiology of the KPC-producing strains .And clinical information of these isolates was analyzed .Results There were 77 carbapenem-resistant Klebsiella pneumoniae isolates in total , and 71 of them were positive in modified Hodge test.Sixty-nine isolates were identified carrying blaKPC-2 gene.All of the KPC-2-producing isolates were classified as the same genotype by ERIC-PCR. Among 12 patients with KPC-2-producing Klebsiella pneumoniae infection who were first identified in each departments , 7 were transferred from other departments, and 4 were treated in surgery intensive care unit (SICU).Conclusions Most of carbpenem-resistant Klebsiella pneumoniae strains isolated from Xinhua Hospital are KPC-2-producing .The outbreak of carbpenem-resistant Klebsiella pneumoniae infection in the hospital may be associated with the interdepartmental transfer of patients .
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Prevalence_studies / Risk_factors_studies langue: Zh Texte intégral: Chinese Journal of Clinical Infectious Diseases Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Prevalence_studies / Risk_factors_studies langue: Zh Texte intégral: Chinese Journal of Clinical Infectious Diseases Année: 2015 Type: Article