Eosinophilic granuloma of bone:imaging manifestations and its pathological basis / 实用放射学杂志

ABSTRACT

Objective To investigate the imaging appearrances and pathological basis of eosinophilic granuloma of bone (EGB)in children and adolescents.Methods X-ray,CT,MRI and pathologic data in 29 cases of EGB which diagnozed by pathology were ret-rospectively analyzed.Results In these 29 cases,24 were solitary lesion and 5 with multiple lesions.The lesions in skull were well defined osteolytic destruction,distinct margin within inner and outer plate involved,as double contour sign and slope sign.The le-sions in limbs showed well defined osteolytic destruction,distinct margin,some reactive osteo-sclerosis,lamellar periosteal reaction and muff sign.The lesions in vertebrae showed well defined typical wedge shape or platyspondyl.Soft tissue swelling and spinal compression could be found in some cases.EGB in uncommon site such as pelvis,clavicle,scapula and irregular bone manifestations showed not specific.MRI showed certain characteristics on adjacent bone marrow edema and swelling of the soft tissue around.On pathology,EGB showed hyperplasia of Langerhans/ cell and infiltration of inflammatory cell.Conclusion There are some specific imaging features of EGB with special pathological basis.But at uncommon sites EGB lacks of specific imaging feature.Combination of the clinic,pathology and imaging can improve the diagnosis accuracy.