Regulatory effect of miRNA enfolded in microparticles on endothelial cells / 中国病理生理杂志

ABSTRACT

Endothelialcellsarethecellsliningtheinnersurfacesofbloodvessels.Theybuildupasinglecell layer and play an important role in the regulation of vascular functions and the maintenance of homeostasis .The activation or injury of endothelial cells is associated with multiple diseases , including hypertension , atherosclerosis, cancer, diabe-tes, etc.Recent studies have found that microparticles are involved in the process of endothelial cell injury , thus playing a part in the development of many diseases .miRNAs enfolded in the microparticles have become importance in recent years . Moreover , recent studies also found that the concentration of the miRNAs enfolded in the microvesicles is higher than that of the miRNAs in the plasma , which means that the microparticles are the main form of miRNAs present in peripheral circula -tory system.This article is to review the recent research progress in microparticle-encapsulated miRNAs and their regulatory effect on endothelial cell injury .