Meconium-stained amniotic fluid and nervous system damage / 中华实用儿科临床杂志

ABSTRACT

For a long time,it was believed that meconium - stained amniotic fluid(MSAF)was caused by fe-tal intrauterine hypoxia induced fetal defecation,once considered synonymous with fetal intrauterine hypoxia. But,MSAF may be a natural phenomenon that mature fetal defecated in intrauterine. Meconium discharge increased and the ability to remove meconium reduced were the important mechanism of the fetal intrauterine distress induced MSAF,when suf-fered from the fetal intrauterine anoxia. MSAF induced damage in the body was associated with the concentration of me-conium,the exposure duration to the meconium amniotic fluid and the causes of meconium discharge. Meconium can di-rectly damage fetal - placental vasculature and promote the release of inflammatory factor,both of them may be involved in the brain injury. The significance of the MSAF and its relationship to brain injury remains for further study.