Change in detection trend and antimicrobial resistance of imipenem-resistant Acinetobacter baumannii from sputum specimens / 中国感染控制杂志

ABSTRACT

Objective To realize detection,antimicrobial resistance,and ward distribution of imipenem-resistant Acinetobacter baumannii (IRAB )from sputum.Methods AB strains isolated from sputum specimens in a hospital between January 1 ,2009 and September 30,2013 were analyzed retrospectively.Ward distribution,antimicrobial resistance,and isolation rates between IRAB and non-IRAB strains were compared.Results 711 AB strains were isolated from sputum,442 of which were IRAB,269 were non-IRAB.AB were mainly distributed in intensive care unit(ICU,39.10%)and neurology department (25.18%);detection rate of IRAB was significantly higher than non-IRAB in ICU (57.47%[n=254]vs 8.92%[n=24],χ2 =165.50,P <0.05),detection rate of IRAB in ICU was significantly higher than non-ICU (91 .37% vs 43.42%,χ2 =257.29,P <0.05).Detection rates of IRAB in 2009-2013 increased continuously (25.30%,36.36%,74.68%,65.56%,and 90.07%,respectively).The resistant rate of IRAB to amikacin was low (27.25%),resistant rates of non-IRAB to amikacin and piperacillin/tazobactam were both low (7.31 % and 8.24% respectively);except compound sulfamethoxazole,resistant rates of IRAB to other antimicrobial agents were all significantly higher than non-IRAB strains (all P < 0.05 ).Conclusion The detection rate and drug resistant rate of IRAB from sputum are both high,early culture,early treatment,and early isolation should be carried out to reduce the emergence of multidrug-resistant organisms.