Biomarkers of cerebral small vessel disease / 国际脑血管病杂志

ABSTRACT

Cerebral smal vessel disease (CSVD) refers to cerebral smal perforating arteries and arterioles (diameter 40 - 200 μm), capilaries, and venules caused syndromes of clinical, cognitive and pathological manifestations. Its imaging classification includes lacunar infarcts, white matter lesions, cerebral microbleed, and perivascular space enlargement, etc. The pathogenesis of CSVD is stil being explored, and imaging findings can not completely reflect the change process of its pathophysiology, especialy the early lesions. Therefore, the difficulties have increased for the prevention and treatment of CSVD. This article summarizes the progress in research on CSVD biomarkers in recent years in order to provide ideas for its etiology, pathogenesis, and clinical prevention and treatment.