Endodermal sinus tumor: immunophenotypic expression of a carcinoma
Journal of Korean Medical Science
;
: 93-100, 1994.
Article
Dans Anglais
| WPRIM
| ID: wpr-48307
ABSTRACT
A series of five endodermal sinus tumors was studied for their cytoskeletal and other phenotypic markers. They included 2 ovarian, 2 testicular, and 1 inguinal tumors. The cytoskeletal expression was also studied by gel electrophoresis and immunoblotting. Every tumor was diffusely and strongly immunostained for cytokeratin. By SDS-PAGE and immunoblotting, cytokeratins 8 & 18 were detected. Vimentin was focally coexpressed in 4 cases. The stroma was diffusely immunostained for vimentin. None of them expressed desmin, neurofilament, or glial filament protein. Desmoplakin was expressed only in one ovarian tumor. Alpha-fetoprotein and S-100 protein were also diffusely positive among the neoplastic cells; intracytoplasmic globules were especially strongly immunostained. These findings suggest that endodermal sinus tumors represent a group of pure malignant epithelial neoplasms, and may be regarded as primitive carcinomas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Immunohistochimie
/
Alphafoetoprotéines
/
Protéines S100
/
Immunophénotypage
/
Tumeur du sac vitellin
/
Protéines du cytosquelette
/
Desmoplakines
Limites du sujet:
Adulte
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
1994
Type:
Article
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