Correlation between fundic gland polyps and colorectal neoplasia:a case?control study / 中华消化内镜杂志

ABSTRACT

Objective To assess the correlation between fundic gland polyps and colorectal neoplasia. Methods Clinical records of patients who underwent both gastroduodenoscopy and colonoscopy during the same period were retrospectively analyzed. A total of 195 patients were enrolled into the study,65 diagnosed as having fundic gland polyps and 130 as controls matched with age and sex. Colonoscopic findings were compared between the two groups. Results Colorectal neoplasia was identified in 12 (18. 5%) of 65 patients and in 8 (6. 2%) of 130 controls with significant difference (P =0. 008) . Stratification analysis suggested that the incidence of colorectal neoplasia in fundic gland polyps group was higher in females or aged less than 50 than that of the control group(P=0. 023,0. 008). Conclusion Patients with fundic gland polyps have significantly higher risk for colorectal neoplasia. A screening colonoscopy may be necessary for patients with fundic gland polyps to detect colorectal neoplasia.