Mechanisms of tumor invasion metastasis caused by long-term anti-angiogenic therapy / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 310-313, 2016.
Article
Dans Zh
| WPRIM
| ID: wpr-485597
Responsable en Bibliothèque :
WPRO
ABSTRACT
Hypoxia results from long-term anti-angiogenic therapy and can stimulate hypoxia-inducible factors (HIFs). HIF-induced hy-poxia signaling is involved in various steps in tumor invasive-metastatic cascade. On the one hand, HIFs regulate epithelial-mesenchy-mal transition. On the other hand, the characteristics of pericytes around vessels and the links among endothelial cells can change;thus, tumor cells can more easily intravasate into blood vessels, survive in peripheral blood, and then reach specific organs, ultimately resulting in metastasis. This review discusses the emerging mechanisms of long-term anti-angiogenic therapy and the occurrence of metastasis.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Clinical Oncology
Année:
2016
Type:
Article