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Study on immune function of blood dendritic cells in patients with lupus nephritis / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 570-572, 2016.
Article Dans Chinois | WPRIM | ID: wpr-485932
ABSTRACT

Objective:

To investigate the different function of dendritic cells between patients with lupus nephritis and healthy control,and discuss the pathogenesis of the disease.

Methods:

Choose 50 healthy controls,50 patients with lupus nephritis,and isolation of blood dendritic cells.Then samples were induced with GM-CSF and IL-4,and cells were collected on day 7.DC maturity was evaluated using the following

methods:

fluorescence-activated cell sorting analysis for cell surface markers;enzyme-linked immunosorbent assay for cytokine production;cell proliferation assay for induction of T cell proliferation.

Results:

Compared with the control group,lupus nephritis group had increased MHC Ⅱ,CD86,CD80,and CD40 expression(P<0.05);displayed the increased IL-12 and TNF-αlevels(P<0.05);displayed a increased ability to drive lymphocyte cells proliferation (P<0.05).

Conclusion:

Compared with the control group ,dendritic cells in lupus nephritis group displayed the mature condition ,which indicates that dendritic cells play the important role in the pathogenesis of lupus nephritis.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Journal of Immunology Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Journal of Immunology Année: 2016 Type: Article