Cardiac Autonomic Function Evaluated by the Heart Rate Turbulence Method was not Changed in Obese Patients without Co-morbidities

ABSTRACT

Obese subjects are more prone to sudden deaths and arrhythmias than non-obese subjects. Heart rate turbulence (HRT) impairment reflects cardiac autonomic dysfunction, in particular impaired baroreflex sensitivity and reduced parasympathetic activity. Our aim was to evaluate the cardiac autonomic function in obesity by the HRT method. Ninety obese subjects and 112 healthy subjects were included in the study. Twenty-four hours ambulatory electrocardiograms were recorded and Holter recordings were analyzed. HRT parameters, turbulence onset (TO) and turbulence slope (TS), were calculated with HRT View Version 0.60-0.1 software program. HRT were calculated in 43 obese and 43 control subjects who had at least one ventricular premature beat in their Holter recordings. We excluded 47 obese patients and 69 control subjects who showed no ventricular premature beats in their Holter recordings from the statistical analysis. There were no significant differences in TO and TS between obese and control subjects (TO obese -1.6+/-2.2%, TO control -2.1+/-2.6%, p>0.05; TS obese 8.2+/-5.2, TS control 10.1+/-6.7, p>0.05, respectively). HRT parameters seem to be normal in obese patients without comorbidities.