Clinical characteristics of 1 006 Chinese patients with lupus erythematosus: results from the Lupus Erythematosus Multicenter Case-control Study in Chinese populations (LEMCSC) / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 6-11, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-488830
ABSTRACT
Objective To explore clinical characteristics of Chinese patients with lupus erythematosus (LE).Methods Data were obtained from the Lupus Erythematosus Multicenter Case-control Study in Chinese populations (LEMCSC).A unified standard was used to recruit patients and collect clinical information.The EpiData 3.1 and SPSS 18 softwares were utilized to input and analyze data respectively.Results One thousand and six patients (87.6% female) with lupus erythematosus (LE) were included in this analysis,of whom,887 (89.9% female) had systemic LE (SLE),and 119 (70.6% female) had isolated cutaneous LE (CLE).The most common involved system in SLE patients was skin (72.7%),followed by joints (69.2%),hematological system (60.8%),kidney (48.5%),serosa (18.2%),and nervous system (5.7%).The appearance of LE-specific skin manifestations was associated with an increased risk of arthritis (odds ratio [OR] =1.612,95% confidence interval [CI]1.181-2.200),but with a decreased risk of nephritis (OR =0.218,95% CI0.157-0.303) and serositis (OR =0.311,95% CI0.218-0.443).The presence of acute CLE (ACLE) lesions was a risk factor for systemic involvement (OR =4.931,95% CI3.232-7.524),while that of chronic CLE (CCLE) lesions was a protective factor for systemic involvement (OR =0.355,95% CI0.234-0.541).The appearance of LE-nonspecific skin manifestations was closely correlated with the involvement of internal organs in patients with LE.Conclusion This study revealed main characteristics of LE patients in China and the relationship between LE-related skin lesions and internal organ involvement.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
/
Facteurs de risque
langue:
Chinois
Texte intégral:
Chinese Journal of Dermatology
Année:
2016
Type:
Article
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