Positive expression of phosphorylated mammalian target of rapamycin in gastric caner and its clinicopathological and prognostic significance: a meta analysis / 中华普通外科杂志

ABSTRACT

Objective To evaluate positive p-mTOR expression and its significance in gastric cancer.Methods Original studies published for the correlation between p-mTOR and clinicopathological parameters as well as prognostic significance were enrolled from Cohrane Library,Pubmed,EMbase database and CBM,CNKI.Analyses were performed by software REVMAN 5.0.Age,gender,TNM stage,lymph node metastasis,type were analyzed using pooled odds ratio (OR) with 95％ confidence interval (CI),and OS were analyzed using pooled hazard ratio (HR) with 95％ CI.Results Seven studies including 2 477 gastric cancer patients were enrolled in the meta analysis.p-mTOR expression was positive in 1 089 of the cases.p-mTOR positive expression was correlated with age,OR =0.74,95％ CI0.62-0.89,dcpth of invasion OR =0.76,95％ CI0.60-0.97,lymph node metastasis,OR =1.95,95％ CI1.59-2.39,TNM stage,OR =0.57,95％ CI0.38-0.84,type,OR =0.64,95％ CI0.50-0.83,and OS,HR =1.86,95％ CI1.60-2.16.Gastric cancer patients with p-mTOR positive expression tend to be younger,had a higher risk of lymphatic invasion,later TNM stage and poor prognosis.Its positive expression had no relation with the gender.Conclusion p-mTOR positive expression is a significant predictor for advanced TNM stage,more lymph node metastasis,intestinal type and poorer OS.