The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
The Korean Journal of Pain
; : 34-39, 2016.
Article
de En
| WPRIM
| ID: wpr-48904
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children. METHODS: A prospective study was conducted in 88 healthy children undergoing tonsillectomy, who received morphine during the operation. The postoperative pain score, frequency of rescue analgesics, and side effects of morphine were assessed in the post-anesthesia care unit. The children were genotyped for OPRM1 A118G, ABCB1 C3435T, and COMT Val158Met. RESULTS: Children with at least one G allele for OPRM1 (AG/GG) had higher postoperative pain scores compared with those with the AA genotype at the time of discharge from the post-anesthesia care unit (P = 0.025). Other recovery profiles were not significantly different between the two groups. There was no significant relationship between genotypes and postoperative pain scores in analysis of ABCB1 and COMT polymorphisms. CONCLUSIONS: Genetic polymorphism at OPRM1 A118G, but not at ABCB1 C3435T and COMT Val158Met, influences the analgesic effect of morphine for immediate acute postoperative pain in children.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Douleur postopératoire
/
Polymorphisme génétique
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Amygdalectomie
/
Études prospectives
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Polymorphisme de nucléotide simple
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Allèles
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Génotype
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Analgésiques
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Analgésiques morphiniques
/
Morphine
Type d'étude:
Observational_studies
Limites du sujet:
Child
/
Humans
langue:
En
Texte intégral:
The Korean Journal of Pain
Année:
2016
Type:
Article