Penetration Enhancers Screening for Compound Ketoconazole Gel / 中国药师
China Pharmacist
;
(12): 685-688, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-490920
ABSTRACT
Objective:
To study the effect of caprylic/capric acid glycerides (Lab), propylene glycol (PG) and Azone on the transdermal behavior of ketoconazole and miconazole nitrate in compound ketoconazole gel, to screen appropriate penetration enhanc-ers.Methods:
Using a RYJ-6A-type transdermal drug diffusion tester, the effects of Lab, PG and Azone at different concentrations on the transdermal behavior of ketoconazole and miconazole nitrate in compound ketoconazole gel were studied.Results:
3% PG showed the most obvious penetration enhancement, which could increase the permeation of ketoconazole by 2. 004 times, and increase the pen-etration of miconazole nitrate by 1. 795 times, and the differences were statistically significant (P<0. 05).Conclusion:
The penetra-tion effect of 3% PG is obvious, which can be applied in compound ketoconazole gel.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude diagnostique
/
Étude de dépistage
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2016
Type:
Article
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