Synthesis and evaluation of new 3-aminooxazolidin-2-one derivatives for inhibiting bacterial quorum sensing / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 476-480, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-492827
ABSTRACT
Objective To develop some 3-aminooxazolidin-2-one derivatives with bacteria quorum sensing(QS)inhibitory ac?tivity. Methods Using(2-hydroxyethyl)hydrazine as raw material,we finished the synthesis through cyclization,condensation,hy?drolysis and condensation reaction,and evaluated their inhibition of QS via Chromobacterium violaceum. Results Eight compounds were synthesized and their structures were confirmed by 1H NMR and MS characterization. Compounds Z2 had inhibitory effect against QS. Conclusion None of the eight synthesized compounds have been reported before and the synthetic route is reliable. Compounds Z2 have inhibitory effect against QS.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of International Pharmaceutical Research
Année:
2016
Type:
Article
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