Developing high quality chemical probes targeting ubiquitin-specific proteases / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 611-619, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-492948
ABSTRACT
Ubiquitin-specific proteases (USPs) regulate the deconjugation of ubiquitin tag from substrate proteins. Dysregulation of USPs has been linked to many diseases. Despite extensive efforts by academia and industry,high quality chemical molecules targeting the USPs family of ubiquitin enzymes are still scarce. In this commentary,I propose the criteria of a high quality chemical probe and the strategies to target USPs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pharmacology and Toxicology
Année:
2016
Type:
Article
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