Effect of glucagon like peptide 1 receptor agonist on blood glucose fluctuation and oxidative stress / 中国综合临床

ABSTRACT

Objective Oxidative stress which participates in the development of diabetes and its complications can induce inflammation and increase the damage and apoptosis on cells and tissue by influencing multiple signaling pathways?Blood glucose fluctuation increased oxidative stress and aggravated damage and apoptosis on cells?The roles of glucagon?like peptide?1 ( GLP?1) receptor agonist can improve blood glucose fluctuation by playing multiple system physiological effects,such as,delaying gastric emptying,reducing appetite, food intake and body weight, enhancing glucose dependent insulin secretion, inhibiting glucose dependent glucagon secretion?In addition,GLP?1 can reduce oxidative stress state by reducing the reactive oxygen species, inhibiting oxidase activity,up?regulating anti?oxidative stress genes,increasing the level of antioxidant enzymes.