Research progress of the relationship between klotho protein and chronic kidney disease / 中国医师杂志
Journal of Chinese Physician
;
(12): 782-785, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-494547
ABSTRACT
Klotho gene is closely related to the aging,which plays an important role in modulation of mineral metabolism,anti-apoptosis,anti-oxidation and antisenescence,etc.Klotho deficiency leads to a syndrome resembling aging,such as shortened life span,atherosclerosis,skin atrophy,hyperphosphatemia,etc.This performance is similar to that of the patients with chronic kidney disease (CKD).The levels of klotho expression and transcription are down-regulated in CKD resulted from various causes.Thus,CKD may be viewed as a state of accelerated aging and/or an age-related disease associated with Klotho deficiency.This article reviewed the relationship between Klotho and CKD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Chinese Physician
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS