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Clinicopathological analysis of seven cases of pemphigoid nodularis / 中华皮肤科杂志
Chinese Journal of Dermatology ; (12): 511-513, 2016.
Article Dans Chinois | WPRIM | ID: wpr-494769
ABSTRACT
Objective To analyze clinical characteristics of pemphigoid nodularis. Methods Seven cases of pemphigoid nodularis were included in this retrospective study. The clinicopathological features of pemphigoid nodularis were retrospectively analyzed, including patientsgender, age at onset, clinical manifestations, treatment and follow?up. Results Of the 7 patients, 4 were female and 3 were male, with the median age at onset being 59 years. Clinical manifestations mainly included markedly pruritic prurigo?like lesions and nodular lesions with or without blisters. The most common misdiagnoses were nodular prurigo and eczema. Pathology showed epidermal hyperplasia and subepidermal clefts, collagen hyperplasia in the papillary dermis, and perivascular infiltration of lymphocytes and eosinophils in the superficial dermis in all the patients. Direct immunofluorescence assay showed linear deposition of IgG and C3 in the basement membrane zone, and indirect immunofluorescence was positive in 2 patients. Glucocorticoids combined with immunosuppressants were effective in all the patients. Conclusions Pemphigoid nodularis is easy to be misdiagnosed, and immunopathology is helpful for its diagnosis. Glucocorticoids combined with immunosuppressants appear to be effective for its treatment.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude observationnelle langue: Chinois Texte intégral: Chinese Journal of Dermatology Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude observationnelle langue: Chinois Texte intégral: Chinese Journal of Dermatology Année: 2016 Type: Article